Selected Publications

  • Curtis LM, Chen S, Chen B, Agarwal A, Klug CA, Sanders PW. Contribution of intrarenal cells to cellular repair after acute kidney injury: subcapsular implantation technique. Am J Physiol Renal Physiol. 2008 Jul;295(1):F310-4.
  • Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med. 2008 Dec 14. [Epub ahead of print]
  • Mu W, Long DA, Ouyang X, Agarwal A, Cruz PE, Roncal CA, Nakagawa T, Yu X, Hauswirth WW, Johnson RJ. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism. Am J Physiol Renal Physiol. 2009 Jan;296(1):F145-52.
  • Li Calzi S, Purich DL, Chang KH, Afzal A, Nakagawa T, Busik JV, Agarwal A, Segal MS, Grant MB. Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes. Diabetes. 2008;57(9):2488-94.
  • George JF, Braun A, Brusko TM, Joseph R, Bolisetty S, Wasserfall CH, Atkinson MA, Agarwal A, Kapturczak MH. Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells. Am J Pathol. 2008 Jul;173(1):154-60.
  • Kie JH, Kapturczak MH, Traylor A, Agarwal A, Hill-Kapturczak N. Heme Oxygenase-1 Deficiency Promotes Epithelial-Mesenchymal Transition and Renal Fibrosis. J Am Soc Nephrol. 2008 Sep;19(9):1681-91.
  • Kumar A, Deshane JS, Crossman DK, Bolisetty S, Yan BS, Kramnik I, Agarwal A, Steyn AJ. Heme Oxygenase-1-derived Carbon Monoxide Induces the Mycobacterium tuberculosis Dormancy Regulon. J Biol Chem. 2008 Jun 27;283(26):18032-18039.
  • Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih DM, Agarwal A, Lusis AJ, Araujo JA. Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res. 2007;100(12):1703-11.
  • Curtis LM, Agarwal A. HOpe for contrast-induced acute kidney injury. Kidney Int. 2007;72(8):907-9.
  • Dulak J, Deshane J, Jozkowicz A, Agarwal A. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation. 2008;117(2):231-41.
  • Deshane J, Chen S, Caballero S, Grochot-Przeczek A, Was H, Li Calzi S, Lach R, Hock TD, Chen B, Hill-Kapturczak N, Siegal GP, Dulak J, Jozkowicz A, Grant MB, Agarwal A. Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. J Exp Med. 2007 Mar 5; 204(3):605-18.
  • Hock TD, Liby K, Wright MM, McConnell S, Schorpp-Kistner M, Ryan TM, Agarwal A. JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. J Biol Chem. 2007 Mar 2;282(9):6875-86.
  • Kirkby K, Baylis C, Agarwal A, Croker B, Archer L, Adin C. Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo. Am J Physiol Renal Physiol. 2007 Feb;292(2):F888-94.
  • Cui T, Schopfer FJ, Zhang J, Chen K, Ichikawa T, Baker PR, Batthyany C, Chacko BK, Feng X, Patel RP, Agarwal A, Freeman BA, Chen YE. Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. J Biol Chem. 2006 Nov 24;281(47):35686-98.
  • Sikorski EM, Uo T, Morrison RS, Agarwal A.Pescadillo interacts with the cadmium response element of the human heme oxygenase-1 promoter in renal epithelial cells. 1: J Biol Chem. 2006:281(34):24423-30.
  • Wright MM, Schopfer FJ, Baker PR, Vidyasagar V, Powell P, Chumley P, Iles KE, Freeman BA, Agarwal A. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4299-304.
  • Hill-Kapturczak N, Agarwal A. Carbon monoxide: from silent killer to potential remedy. Am J Physiol Renal Physiol. 2006;290:F787-8.
  • Chen S, Wasserfall C, Kapturczak MH, Atkinson M, Agarwal A. Freeze-thaw increases adeno-associated virus transduction of cells. Am J Physiol Cell Physiol. 2006:291(2):C386-92.
  • Zhou H, Liu H, Porvasnik SL, Terada N, Agarwal A, Cheng Y, Visner GA. Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension. Lab Invest. 2006;86:62-71.
  • Basireddy M, Isbell TS, Teng X, Patel RP, Agarwal A. Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidney. Am J Physiol Renal Physiol. 2006;290:F779-86.
  • Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, Cruz PE, Roncal CA, Glushakova OY, Chiodo VA, Atkinson MA, Hauswirth WW, Flotte TR, Rodriguez-Iturbe B, Johnson RJ. IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol. 2005;16:3651-60.
  • Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res. 2005;65:4789-98.
  • Brusko TM, Wasserfall CH, Agarwal A, Kapturczak MH, Atkinson MA. An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells. J Immunol. 2005;174:5181-6.
  • Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Hauswirth WW, Madsen KM, Croker BP, Berns, KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A. Interleukin-10 attenuates neointimal proliferation and inflammation in aortic allografts via a heme oxygenase dependent pathway. Proceedings of The National Academy of Sciences, USA 2005;102:7251-7256.
  • Chen S, Kapturczak MH, Loiler SA, Zolotukhin S, Glushakova OY, Madsen KM, Samulski RJ, Hauswirth WW, Berns KI, Flotte TR, Atkinson MA, Tisher CC, Agarwal A. Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human Gene Therapy 2005;16:235-247.
  • Adin CA, Croker BP, Agarwal A. Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated perfused rat kidney. American Journal of Physiology, Renal Physiology 2005;288:F778-F784.
  • Sikorski EM, Hock TD, Hill-Kapturczak N, Agarwal A. The story so far…Molecular regulation of the heme oxygenase-1 gene in renal injury. Invited review. American Journal of Physiology (Renal). 2004;286:F425-F441.
  • Hock TD, Nick HS, Agarwal A. Upstream stimulatory factors, USF1 and USF2 bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription. Biochemical Journal 2004;383:209-218.
  • Kapturczak MH, Wasserfall C, Brusko T, Campbell-Thompson M, Ellis TM, Atkinson MA, Agarwal A. Heme Oxygenase-1 Modulates Early Inflammatory Responses: Evidence from the Heme Oxygenase-1 Deficient Mouse. American Journal of Pathology 2004;165:1045-1053.
  • Chen S, Segal MS, Agarwal A. “Lumen digestion” technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout mice. Biotechniques 2004;37:84-89.
  • Davis CA, Hearn AS, Fletcher B, Bickford J, Garcia JE, Leveque V, Melendez JA, Silverman DN, Zucali J, Agarwal A, Nick HS. Potent anti-tumor effects of an active site mutant of human MnSOD: Evolutionary conservation of product inhibition. Journal of Biological Chemistry 2004;279:12769-12776.
  • Zhou X, Yang G, Davis CA, Doi SQ, Hirszel P, Wingo CS, Agarwal A. Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells. Kidney International 2004;65:139-147.