Selected Publications

Chattopadhyay, D., Langsley, G., Carson, M., Recacha, R., DeLucas, L.J. & Smith, C. D. (2000) Crystal structure of the Nucleotide Binding Domain of Plasmodium falciparum Rab6 GTPase in the GDP Bound Form. Acta Cryst D. Biol. Crystallography 56, 937-944

  • Recacha, R., Costanzo, M.J., Maryanoff, B. & Chattopadhyay, D. (2002) Crystal Structure of Human Carbonic Anhydrase II Complexed with an Anticonvulsant Sugar Sulfamate. Biochem. J. 361, 437-441.
  • Costanzo, M. J, Yabur, S. C, Almond Jr., H. R., Andrade-Gordon, P, Corcoran, T. W., de Garavilla, L., Kauffman, J. A., Abraham, W. M., Recacha, R, Chattopadhyay, D. and Maryanoff, B. E. (2003) Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone J. Med. Chem. 46, 3865-3876
  • Greco, M.N., Hawkins, M.J., Powell, E.T., Almond, H.R., Corcoran, T.W., Garavilla,L., Kauffman, J.A., Recacha, R., Chattopadhyay, D., Andrade-Gordon, P. & Maryanoff, B.E. (2002) Nonpeptide inhibitors of Cathepsin G: optimization of a novel b-ketophosphonic acid lead by structure-based drug design. J. Am. Chem. Soc. 124, 3810-3811.
  • Quevillon, E., Spielmann, T., Brahimi, K., Chattopadhyay, D., Yeraman, E. & Langsley, G. (2003) The Plasmodium falciparum family of RabGTPases. Gene 306, 13-25
  • Senkovich, O., Pal, B., Schormann, N.S. & Chattopadhyay, D. (2003) Trypanosoma cruzi genome encodes a pteridine reductase 2 protein. Mol. Biochem. Parasitol. 127. 89-92
  • Schormann, N., Senkovich, O., Ananthan, S. & Chattopadhyay, D. (2003) Docking and Biological Activity of Pteridine Analogs: Search for Inhibotors of Pteridine Reductase Enzymes from Trypanosoma cruzi. THEOCHEM 635, 37-44
  • Costanzo, M. J, Yabur, S. C, Almond Jr., H. R., Andrade-Gordon, P, Corcoran, T. W., de Garavilla, L., Kauffman, J. A., Abraham, W. M., Recacha, R, Chattopadhyay, D. and Maryanoff, B. E. (2003) Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone J. Med. Chem. 46, 3865-3876
  • Senkovich, O., Bhatia, V., Garg, N. & Chatopadhyay, D. (2005) Lipophilic Antifolate Trimetrexate is a Potent Inhibitor of Trypanosoma cruzi Antimicrob. Chemother. Antimicrob. Chemother. 49, 3234-323
  • Schormann, N., Pal, B., Senkovich, O., Smith, C., Carson, M., Howard, A., DeLucas, L. & Chattopadhyay, D. (2005) Crystal structure of Trypanosoma cruzi Pteridine Reductase J. Structural Biol. 152, 64-75
  • Chattopadhyay, D., Rayner, J., McHenry, A.M., and Adams, J. H. (2006) The 3D structure of Plasmodium falciparum EBA175 ligand domain provides unexpected insight into the molecular basis of host specificity for malaria parasites. Trends in Parasitology 22, 143-145
  • Samal, A., Schormann, N., Cook, W. J., DeLucas, L. J. & Chattopadhyay, D. (2007) “Structures of vaccinia virus dUTPase and its nucleotide complexes”. Acta Cryst. D Biol. Crystallography 63, 571-580.
  • Senkovich, O., Cook, W. J., Mirza, S., Holligshead, S. K., Protasevich, I. I., Briles, D. E. & Chattopadhyay, D. (2007) “Structure of a Complex of Human Lactoferrin N-lobe with Pneumococcal Surface Protein A Provides Insight into Microbial Defense Mechanism”. J. MOl. Biol. 370, 701-713.
  • Schorann, N., Grigorian, A., Samal, A., Raman, K., DeLucas, L. & Chattopadhyay, D. (2007)”Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly”. BMC Struct. Biol. 7, 45
  • Schormann N, Senkovich O, Walker K, Wright DL, Anderson AC, Rosowsky A, Ananthan S, Shinkre B, Velu S, Chattopadhyay D. (2008) “Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function” Proteins 73, 889-901
  • Prichard, M., Keith, K. A., Johnson M., Harden, E. A., Luo, M., Qiu, S., Chattopadhyay, D. Fan, X., Torrence, P. F. & Kern, E. R. (2007) Selective Activation of Antiviral Drugs by the Vaccinia Virus Thymidine Kinase Antimicrob. Agent Chemother. 51, 1795-1803.
  • Cook, W. J., Senkovich, O. & Chattopadhyay, D. (2009) “An unexpected phosphate binding site in Glyceraldehyde 3-Phosphate Dehydrogenase: Crystal structures of apo, holo and ternary complex of Cryptosporidium parvum enzyme” BMC Structural Biology 9, 9.
  • Senkovich, O., Schormann, N. & Chattopadhyay, D. (2009) “Structures of Trypanosoma cruzi Dihydrofolate reductase thymidylate synthase in the folate-free state and in complex with two antifolate drugs, Trimetrexate and Methotrexate” Acta Cryst. D Biol. Crystallogr. D65, 704-716.